Abstract #3163

Reproducibility of pH-Weighted Chemical Exchange Saturation Transfer (CEST) Contrast in the Healthy Cervical Spinal Cord

Alicia Cronin^1,2, Patrick Liebig³, Sarah Detombe⁴, Neil Duggal^1,4, and Robert Bartha^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, London, ON, Canada

Synopsis

Keywords: CEST & MT, Spinal CordIschemia and hypoxia can occur in the spinal cord due to several conditions, including compression and injury; however, in-vivo measurements of ischemia have been challenging. Chemical Exchange Saturation Transfer (CEST) can produce pH-weighted contrast, which is an indicator of tissue hypoxia. The purpose of this study was to optimize pH-weighted CEST contrast in the healthy cervical spinal cord using a prototype 3D CEST sequence on a 3T Siemens Prisma Fit MRI and determine the reproducibility of measurements at various levels along the cervical spinal cord.

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