Abstract #3167

Can pH can be a marker of hypoxia? Role of MRI CEST pH imaging in differentiating hypoxic from non-hypoxic tumors.

Aruna Singh^1,2, Julia Stabinska^1,2, Balaji Krishnamachary¹, Kuldeep Gupta¹, Farzad Sedaghat³, Sridhar Nimmagadda¹, Jeff W. M. Bulte¹, Zaver M. Bhujwalla¹, and Michael T. Mcmahon^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: CEST & MT, CEST & MT, CEST MRI, hypoxia, acidosis, pH, Iopamidol, breast cancer, HIF-1 alpha

Acidosis and hypoxia play a key role in developing metastasis and chemoresistance in tumors. pH measurement can be used as indicator of hypoxia and can provide insights into the metastatic potential of tumors. This study have explored chemical exchange-dependent saturation transfer (CEST) MRI based pH imaging to differentiate between two types of breast tumor models differing in their Hypoxia Inducible Factor-1α (mediator for hypoxia related adaptations in tumors) expression. Tumor acidification was observed in both with lower average extracellular pH (pHe = 6.1) in tumors with intact HIF-1α expression compared to those with HIF-1α silenced group (pHe = 6.2).

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