Keywords: CEST & MT, Alzheimer's DiseaseThis study utilizes nuclear Overhauser effect (NOE) MRI to map early-stage changes in macromolecular brain content of an APPNL-F model of Alzheimer's disease. NOEMTR and rNOE are the quantitative metrics used to assess lipids and proteins in major regions of the mouse brain. Following ROI analysis, there is a statistically significant decrease in NOEMTR contrast between wild-type and AD mice in the hippocampus, with rNOE showing a similar trend with a strong suggestion of statistical significance. Overall, this study shows that NOE MRI can be used to successfully detect changes in the macromolecular content of mouse brain tissue through NOEMTR.
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