Abstract #3175

Novel contrast agents for MR based on chemical exchange saturation transfer and its potential applications

Yanlong Jia¹, Feng Wu¹, Lin Yang², Beibei Chen², Yazhi Zhong³, Renhua Wu², and Feng Li¹

¹Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China, ²Department of Radiology, Second Affiliated Hospital, Shantou University Medical College, Shantou, China, ³Department of Radiology, Huizhou central people's hospital, Huizhou, China

Synopsis

Keywords: CEST & MT, Molecular ImagingThis study aimed to investigate some small molecular compounds with an appropriate chemical exchange site that can be employed as negative contrast agents for magnetic resonance imaging. 17 kinds of small molecular substances were selected and the imaging were performed on 7.0T MR system. Except for biotin, a series of small molecular substances have the characteristics of CEST. Salicylic acid (9.3ppm), 5-aminosalicylic acid (8.0ppm), and olsalazinesodium (9.8ppm) have large frequency offset, with optimal pH value 6.4～6.8, which are ideal candidates for CEST contrast agents. Due to the differences of molecular structure, the CEST characteristics were different.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.