Abstract #3176

Respiratory Modulation of Cerebrospinal Fluid Flow During Paced Breathing

Makaila Banks¹, Nicholas Cicero¹, Daniel Gomez^2,3, Ewa Beldzik⁴, Vitaly Napadow^2,3, Jonathan Polimeni^2,3, and Laura Lewis⁴

¹Neuroscience, Boston University, Boston, MA, United States, ²Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, Charlestown, MA, United States, ⁴Biomedical Engineering, Boston University, Boston, MA, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Cerebrospinal Fluid, CSFWe used flow-sensitive fMRI to explore the effect of paced respiration on cerebrospinal fluid (CSF) flow. Results indicate that paced breathing tasks at rates between 0.1 Hz and 0.25 Hz increase CSF flow. All breathing paces showed a striking increase in CSF inflow-enhanced signals with the highest group-averaged amplitude being 26% during the 0.1 Hz breathing task. We conclude that diaphragmatic paced breathing is an effective modulator of CSF flow that may represent increased fluid transport relative to free breathing.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.