Keywords: Neurofluids, Arterial spin labelling, Blood-Brain BarrierArterial spin labeling (ASL) MRI is noninvasive and has the potential to become a sensitive, clinically useful way to measure blood-brain barrier (BBB) permeability. Here, we focused on two different ASL sequences, diffusion-weighted (DW) and multi-echo (T2), and performed simulations to compare the robustness of BBB permeability (Texch) measurement to different levels of noise. We conclude that the Texch fitting for DW ASL is more robust to noise at a physiological arterial transit time (ATT) of 1000ms at the expense of being more vulnerable to bias when the assumed ATT deviates from the true underlying ATT.
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