Abstract #3178

Perivascular Space Imaging during Therapy for Medulloblastoma

Ruitian Song¹, John O. Glass¹, Giles W. Robinson², Amar Gajja³, Thomas E. Merchant⁴, and Wilburn E. Reddick¹

¹Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, United States, ²Oncology, St Jude Children's Research Hospital, Memphis, TN, United States, ³Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, United States, ⁴Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN, United States

Synopsis

Keywords: Neurofluids, Brain, Perivascular Space Imaging

Patients with medulloblastoma treated with radio-chemotherapy (N=211) were examined by perivascular space (PVS) imaging at three time points: 0, 3, and 12 months. The patients were treated with different dose level based on risk factors. For low dose radiation, there were no significant changes in PVS between time points. A transient increase in PVS was observed for high and standard dose radiation during radiotherapy which subsequently resolved during chemotherapy. Perivascular space imaging is a potential biomarker to monitor the side effects from combined modality therapy.

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