Abstract #3179

Alterations of brain motion in idiopathic intracranial hypertension (IIH) based on amplified MRI (aMRI)

Haribalan Kumar^1,2,3, Matthew Mcdonald^3,4, Alireza Sharifzadeh², Jet Wright³, Eryn Kwon^2,3, Leigh Potter³, Paul Condron^3,5, Taylor Emsden^3,5, Daniel Cornfeld³, Graham Wilson^3,6, David Freschini⁶, David Dubowitz⁷, Miriam Scadeng⁷, Helen Danesh-Meyer^4,8, Samantha Holdsworth^3,7, Sarah-Jane Guild^2,9, Soroush Safaei², and Gonzalo Maso Tolou²

¹GE Healthcare, Gisborne, New Zealand, ²Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ³Mātai Medical Research Institute, Gisborne, New Zealand, ⁴Department of Opthalmology, University of Auckland, Auckland, New Zealand, ⁵Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁶Chelsea Hospital, Gisborne, New Zealand, ⁷Department of Anatomy & Medical Imaging, Faculty of Medical and Health Sciences, Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁸Eye Institute, Auckland, New Zealand, ⁹Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Synopsis

Keywords: Neurofluids, Brain, IIH, Intracranial PressureHeartbeat-driven brain motion has historically remained limited to the domain of research. Such motion may provide a window to characterise parenchymal and CSF pressures where direct, invasive measurements are disruptive and difficult to justify. Amplified MRI (aMRI) is a recently developed method which amplifies subtle brain motion. We show preliminary data that aMRI can be used to detect changes in brain motion associated with increased intracranial pressure in idiopathic intracranial hypertension (IIH), suggesting a potential non-invasive method for evaluating pressure levels of the subarachnoid space in patients with altered intracranial pressure.

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