Abstract #3185

Concurrent measurement of perfusion parameters related to small blood and lymphatic vessels in the human brain

Di Cao^1,2,3, Yuanqi Sun^1,2,3, Su Pan⁴, Jay J. Pillai^5,6,7, Ye Qiao⁵, Hanzhang Lu^1,2,3, Peter C.M. Van Zijl^1,2, Linda Knutsson^1,2,8, and Jun Hua^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ³Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴School of Medicine, University of Maryland, Baltimore, MD, United States, ⁵Neuroradiology, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ⁶Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States, ⁷Neuroradiology, Mayo Clinic, Rochester, MN, United States, ⁸Department of Medical Radiation Physics, Lund University, Lund, Sweden

Synopsis

Keywords: Neurofluids, DSC & DCE PerfusionAccumulating evidence has indicated the importance of studying the interaction between the microvascular and lymphatic systems in the brain. To date, most imaging methods can only measure blood or lymphatic vessels separately. This study proposes an MRI approach for concurrent measurement of perfusion parameters related to small blood and lymphatic vessels within one single scan. A dual-echo TSE sequence was optimized for the measurement of gadolinium(Gd)-induced blood and CSF signal changes. The proposed method showed consistent results in human brains as previous studies using separate methods. Signal changes from small blood vessels occurred faster than lymphatic vessels after intravenous Gd-injection.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.