Abstract #3186
Abnormal glymphatic system function in patients with chronic migraine using diffusion tensor image analysis along the perivascular space
Xue Zhang1,2, Wei Wang3, Xueyan Zhang4, Xiaoyan Bai1,2, Ziyu Yuan3, Ruiliang Bai5,6,7, Bingjie Jiao6, Yingkui Zhang2, Zhiye Li1,2, Peng Zhang3, Hefei Tang3, Yaqing Zhang3, Xueying Yu3, Yonggang Wang3, and Binbin Sui2
1Department of Radiology, Beijing Tiantan hospital, Capital Medical University, Beijing, China, 2Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China, 3Headache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 5Department of Physical Medicine and Rehabilitation of the Affiliated Sir Run Shumen Shaw Hospital and Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China, 6key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, 7MOE Frontier Science Center for Brain Science and Brain-machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China
Synopsis
Keywords: Neurofluids, Diffusion Tensor Imaging, HeadacheChronic migraine (CM) is a common and highly disabling primary headache associated with vasomotion dysfunction. It is unclear whether glymphatic dysfunction develops due to frequent and chronic headache attacks in CM. In the current study, we evaluated the glymphatic system function in patients with CM using diffusion tensor image analysis along the perivascular space (DTI-ALPS) technique. We found a significantly higher ALPS index compared with healthy controls, and the alteration was significant only observed in the right hemisphere. Patients with CM have abnormalities in glymphatic function, and the right-prominent alterations might be a certain feature of CM.
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