Abstract #3188
Cross vendors test-retest validation of diffusion tensor image analysis along the perivascular space for evaluating glymphatic system function
Xiaodan Liu1,2,3, Giuseppe Barisano4, Xingfeng Shao3, Kay Jann3, Hanzhang Lu5, Konstantinos Arfanakis6,7, Arvind Caprihan Caprihan 8, Charles DeCarli9, Brian T. Gold10, Pauline Maillard9, Clandia L. Satizabal11, Elyas Fadaee12, Mohamad Habes12, Lara Stables13, Herpreet Singh14, Bruce Fischl15,16,17,18, Andre van der Kouwe15,18,19, Kristin Schwab14, Karl G. Helmer15,18,19, Steven M. Greenberg14, and Danny JJ Wang3
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Zilkha Neurogenetic Institue, University of Southern California, Los Angeles, CA, United States, 3Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 4Neurosurgery, Stanford University, Palo Alto, CA, United States, 5Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 7Diagnostic Radiology and Nuclear Medicine, Rush University, Chicago, IL, United States, 8The Mind Research Network, Albuquerque, NM, United States, 9Neurology, University of California, Davis, Davis, Davis, CA, United States, 10Neuroscience, University of Kentucky, Lexington, KY, United States, 11Population Health Sciences and Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 12Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 13Neurology, University of California, San Francisco, San Francisco, CA, United States, 14Neurology, Massachusetts General Hospital, Boston, MA, United States, 15Radiology, Harvard Medical School, Boston, MA, United States, 16Athinoula A. Martinos Center for Biomedical Imaging,Massachusetts General Hospital, Charlestown, MA, United States, 17Computer Science and AI Lab, Massachusetts Institute of Technology, Cambridge, MA, United States, 18Radiology, Massachusetts General Hospital, Boston, MA, United States, 19Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States
Synopsis
Keywords: Neurofluids, Brain, glymphatic systemThe diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies validate its reliability and reproducibility. 50 participants’ DTI data from the MarkVICD consortium were recruited in this study. Two pipelines by using DSI studio and FSL software were developed for data processing and ALPS-index calculation. The mean ALPS-index was obtained by the average of bilateral ALPS-index and was used for testing the cross vendors test-retest reliability by using R studio. Mean ALPS-index demonstrated favorable inter-scanner reproducibility, inter-rater reliability and test-retest repeatability, offering a potential biomarker for GS function.
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