Keywords: Neurofluids, BrainThe cerebrospinal fluid plays an essential role in cerebral homeostasis, contributing to the delivery of oxygen and nutrients to brain tissue as well as clearing waste products. However, the mechanisms and functions of CSF oxygenation and their potential disturbance in pathology remain unknown. Dissolved O2 shortens T1 of water due to its paramagnetic properties. Because of its extremely long T2, selective CSF imaging can be achieved by using extremely long TE (>500ms) Spin-Echo based acquisitions. Therefore, we report here a study using ultra long TE Fluid-Attenuated Inversion Recovery to image baseline CSF oxygenation with minimal tissue contribution.
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