Abstract #3195

Reductions in nigral volume of de novo and moderate Parkinson’s disease patients

Jason Langley¹, Kristy Hwang², Daniel Huddleston³, and Xiaoping Hu^1,4

¹Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, ²2Department of Neurosciences, University of California San Diego, San Diego, CA, United States, ³Department of Neurology, Emory University, Atlanta, GA, United States, ⁴Department of Bioengineering, University of California Riverside, Riverside, CA, United States

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, substantia nigraNeuronal loss in substantia nigra pars compacta is a hallmark of Parkinson's disease. In this abstract, we examine nigral volume in a group without Parkinson's disease (non-carriers, non-manifest LRRK2 and GBA mutations), de novo Parkinson's disease, and moderate Parkinson's disease. Reductions in nigral volume are seen in the Parkinson's disease groups relative to the group without Parkinson's disease. A further reduction is seen in nigral volume of the moderate Parkinson's disease group relative to the de novo group, suggesting that nigral degeneration continues as Parkinson's disease progresses.

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