Abstract #3200

Glymphatic system impairment in Parkinson’s disease with rapid movement sleep behavior disorder

Amei Chen¹, Junxiang Huang², Xiaofei Huang¹, Xiaofang Cheng³, Yongzhou Xu⁴, and Xinhua Wei¹

¹Guangzhou First People's Hospital, Guangzhou, China, ²Guangzhou Women and Children's Medical Center, Guangzhou, China, ³The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Parkinson's Disease, Diffusion Tensor Imaging, glymphatic system；rapid movement sleep behavior disorderTo assess the activity of the glymphatic system in PD patients with probably rapid movement sleep behavior disorder (PD-pRBD) using diffusion tensor image analysis along the perivascular space( DTI-ALPS) index. 61 PD-pRBD, 92 PD patients with no probable RBD(PD-npRBD) and 59 healthy control (HC) were included in the study. The results showed that the ALPS index in PD-pRBD group was lower than that in PD-npRBD group. The index of ALPS in PD-pRBD was negatively correlated with REM sleep behavior disorder screening questionnaire(RBDSQ) score. We concluded that the glymphatic system function of PD with RBD is impaired.

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