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Abstract #3203

Functional and Microstructural Comparative Study on Monogenic vs Idiopathic Parkinson's Disease

Hacer Dasgin1, Basak Soydas Turan2, Bilge Volkan Salanci3, Eser Lay Gun2, Gul Yalcin Cakmakli3, Bulent Elibol3, and Kader K. Oguz1,4,5
1Umram, Bilkent University, Ankara, Turkey, 2Faculty of Medicine, Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey, 3Faculty of Medicine, Department of Neurology, Hacettepe University, Ankara, Turkey, 4Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey, 5University of California, Davis, CA, United States

Synopsis

Keywords: Parkinson's Disease, fMRI (resting state)Clinical presentation of monogenic PD differs from idiopathic PD, which might relate to different structural and functional alterations. Previously, we examined a small group of genetic PD patients with connectivity changes in the basal ganglia, compared with healthy control (HC)s. In this study we further examined monogenic PD patients and compared idiopathic PD group and HCs that functional and microstructural changes would be different in these groups of patients. There was no significant basal ganglia network (BGN) alteration between PD groups, but ACC activation is remarkable in both groups. Significantly decreased fractional anisotropy in mPD patients compared to iPD patients.

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Keywords