Keywords: Parkinson's Disease, fMRI (resting state)Clinical presentation of monogenic PD differs from idiopathic PD, which might relate to different structural and functional alterations. Previously, we examined a small group of genetic PD patients with connectivity changes in the basal ganglia, compared with healthy control (HC)s. In this study we further examined monogenic PD patients and compared idiopathic PD group and HCs that functional and microstructural changes would be different in these groups of patients. There was no significant basal ganglia network (BGN) alteration between PD groups, but ACC activation is remarkable in both groups. Significantly decreased fractional anisotropy in mPD patients compared to iPD patients.
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