Keywords: Parkinson's Disease, NeurodegenerationDiagnosing movement disorders (MDS) is a major challenge clinically. Neuromelanin and iron serve as biomarkers for MDS but few studies have evaluated a large number of cases for multiple disorders. We studied 614 patients consisting of two cohorts with different resolutions. The QSM and NM-MRI data were automatically processed using a unique template program. The results from both cohorts showed reproducible changes of iron and neuromelanin in the deep gray matter. Specifically, a loss of neuromelanin volume, an increase in iron content of the SN for both PD and MSA; increased RN iron and decreased putamen volume in MSA.
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