Abstract #3205

Exploring the effects of tissue iron in neuromelanin MRI

Minjun Kim¹, Sooyeon Ji¹, Joonhyeok Yoon¹, Hwihun Jeong¹, Hongjun An¹, Jiye Kim¹, Jonghyo Youn¹, Junghwa Kang², Eung Yeop Kim³, Yoonho Nam², and Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do, Korea, Republic of, ³Department of Radiology, Samsung Medical Center, Seoul, Korea, Republic of

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Neuromelanin MRI signal decreases in IPD patients in the substantia nigra. In this study, we investigated that the decrease is caused by not only the reduction of neuromelanin but also iron deposition. Neuromelanin reduction in IPD patients was shown by the result of the substantia nigra volume decrease. The comparison result of contrast ratio, calculated between substantia nigra and crus cerebri, of IPD patients versus healthy controls demonstrated that iron deposition also decreases the signal of NM-MRI. T₂*, susceptibility, and overlapped area between substantia nigra from neuromelanin MRI and hypo-intense area from SMWI also represented the tendency of iron deposition.

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