Keywords: Parkinson's Disease, Brain ConnectivityDevelopment of more clinically effective and quantifiable biomarkers to detect PD is urgently needed. It confirmed that regional radiomics similarity network (R2SN) had high reproducibility and a biological basis and provided a new perspective for understanding the human brain. Our study showed that R2SN constructed based on ALFF had good reproducibility and stability, and is biological plausibility. We found PD-related brain regions mainly located in the default-mode, sensorimotor, executive control, visual, frontoparietal network, as well as cerebellum, and striatum. ALFF-based R2SN is a novel, robust potential neuroimaging biomarker for PD and could provide new insights into connectome reorganization in PD.
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