Keywords: Parkinson's Disease, Multimodal, Dopamine, free-water DTI, IronFDOPA uptake rate, fractional volume of free-water and R2* relaxometry are imaging biomarkers sensitive to dopaminergic decline, microstructural degeneration, and iron disruption respectively, three pathological processes developed within the nigrostriatal system in Parkinson’s disease (PD). A multimodal comprehensive characterization of these biomarkers in early PD was performed, assessing them within striatum and substantia nigra pars compacta in a de novo PD cohort. While iron disruption was not observed, PD subjects revealed dopaminergic and microstructural alterations within the nigrostriatal system, following both similar spatial patterns. These results serve to improve our understanding of nigrostriatal vulnerability and degeneration in early PD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords