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Abstract #3214

Dynamic characteristics of functional network activity in brains with left-frontal glioma

Siqi Cai1,2, Yuchao Liang3, Yinyan Wang3, Yufei Liu4, Fanfan Chen4, Chunxiang Jiang1,2, Lei Wang3, and Lijuan Zhang1,2
1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Science, Beijing, China, 3Beijing Tiantan Hospital of Capital Medical University, Beijing, China, 4Shenzhen Second People's Hospital, Shenzhen, China

Synopsis

Keywords: Tumors, fMRI (resting state)This study investigated the temporal features of the brain network activity with dynamic fractional amplitude of low-frequency fluctuation (dfALFF) and sliding window approach. The time-varying brain activity was clustered into two distinct states. Patients’ brains featured high occurrence of the weak state, low occurrence of the strong state, and network dALFF that decreased but spatially extended with the tumor malignancy. The dfALFF variance of networks was attenuated in HGGs but not LGGs. These malignancy-specific alterations indicate a diverse neuropathological profile of gliomas, and highlight the importance of temporal features of brain activity in the disease characterization of glioma.

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Keywords