Abstract #3223

Magnetic Resonance Spectroscopic Correlates of Survival in IDH-wt, TERTp-mut Gliomas

Banu Sacli-Bilmez¹, Ayça Erşen Danyeli^2,3, Cengiz Yakicier⁴, M.Necmettin Pamir^3,5, Koray Özduman^3,5, Alp Dinçer^3,6, and Esin Ozturk-Isik^1,3

¹Institute of Biomedical Engineering, Boğaziçi University, İstanbul, Turkey, ²Department of Medical Pathology, Acıbadem University, İstanbul, Turkey, ³Brain Tumor Research Group, Acıbadem University, İstanbul, Turkey, ⁴Department of Molecular Biology and Genetics, Acıbadem University, İstanbul, Turkey, ⁵Department of Neurosurgery, Acıbadem University, İstanbul, Turkey, ⁶Department of Radiology, Acıbadem University, İstanbul, Turkey

Synopsis

Keywords: Tumors, BrainThe 2021 central nervous system tumor classification has suggested that isocitrate dehydrogenase wildtype (IDH-wt) WHO grade-2/3 astrocytomas with molecular features of glioblastoma should be designated as “Glioblastoma, IDH-wildtype, WHO grade-4”. In this study, we explored metabolic correlates of patient survival in tumors fulfilling the criteria for “Glioblastoma, IDH-wildtype, WHO grade-4” using short echo time (TE) single voxel ¹H-MRS. The results of this study suggest that higher ratios of glutamine and glutamate complex (Glx) to total creatine (tCr) and glutathione (GSH) to tCr were associated with a shorter survival.

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