Meeting Banner
Abstract #3224

Effects of radiotherapy on tissue in patients with brain metastases in terms of OEF and CMRO2

Jordi de Leeuw1, Junghun Cho2, Eva van Grinsven3, Jeroen Siero4, Marielle Philippens4, and Alex Bhogal4
1Imaging Division, UMC Utrecht, Utrecht, Netherlands, 2SUNY Buffalo, Buffalo, NY, United States, 3Brain Department, Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 4Radiology Department, UMC Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Tumors, Metabolism

Radiotherapy might have an influence on the ratio of deoxygenated versus oxygenated blood in the venous blood vessels (OEF) in the brain. The relationship between delivered dose and the OEF may be a more direct measure of tissue damage or recovery. Preliminary results suggest that there is a marginal significant increase in OEF values after radiotherapy. This indicates that OEF can be of valuable use in determining the effects of radiotherapy. Additionally, CMRO2 maps show an identical increase or decrease in cerebral metabolic activity.

Keywords: Oxygen extraction fraction Cerebral metabolic rate of oxygen extraction Radiotherapy Brain tumor

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords