Abstract #3224

Effects of radiotherapy on tissue in patients with brain metastases in terms of OEF and CMRO2

Jordi de Leeuw¹, Junghun Cho², Eva van Grinsven³, Jeroen Siero⁴, Marielle Philippens⁴, and Alex Bhogal⁴

¹Imaging Division, UMC Utrecht, Utrecht, Netherlands, ²SUNY Buffalo, Buffalo, NY, United States, ³Brain Department, Radiotherapy, UMC Utrecht, Utrecht, Netherlands, ⁴Radiology Department, UMC Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Tumors, Metabolism

Radiotherapy might have an influence on the ratio of deoxygenated versus oxygenated blood in the venous blood vessels (OEF) in the brain. The relationship between delivered dose and the OEF may be a more direct measure of tissue damage or recovery. Preliminary results suggest that there is a marginal significant increase in OEF values after radiotherapy. This indicates that OEF can be of valuable use in determining the effects of radiotherapy. Additionally, CMRO2 maps show an identical increase or decrease in cerebral metabolic activity.

Keywords: Oxygen extraction fraction Cerebral metabolic rate of oxygen extraction Radiotherapy Brain tumor

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