Abstract #3231

The Effect of RF Pulse Duration Settings in Basis Sets on Sensitivity and Specificity of 2HG Spectroscopy

Sanghoon Kim¹, Changho Choi², Natasha Najam¹, and Alexander Lin¹

¹BWH, Boston, MA, United States, ²Vaderbilt University Institute of Imaging Science, Nashville, TN, United States

Synopsis

Keywords: Tumors, Spectroscopy, 2HG detection2HG is the specific biomarker for the IDH mutation in tumors. In this study, we utilized two different 2HG basis sets, one using a 4.8ms refocusing pulse duration and another with 5.8ms. Using the two different basis sets, we analyzed the same data and found large differences in the sensitivity and specificity results.

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