Abstract #3236

Dual-site and dual-vendor comparison of cerebral oxygen extraction fraction by ASE and TRUST MRI in identical participants

Chunwei Ying¹, Spencer Waddle², Nkemdilim Igwe³, Niral J. Patel⁴, Alexander K. Song², Charu Balamurugan⁴, Lori C. Jordan⁴, Dengrong Jiang⁵, Hanzhang Lu⁵, Andria L. Ford³, Manus J. Donahue², and Hongyu An^1,3

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, United States, ²Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Neurology, Washington University School of Medicine, St Louis, MO, United States, ⁴Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Data Analysis, Brain, repeatability; reproducibilityWe evaluated dual-site and dual-vendor test-retest repeatability and reproducibility of cerebral oxygen extraction fraction (OEF) measured with asymmetric spin echo (ASE) and T2-Relaxation-Under-Spin-Tagging (TRUST) MRI. The intra-site intra-class correlation coefficient (ICC) of global ASE-OEF were 0.952 and 0.919 for each site. The intra-site ICC of TRUST-OEF based on the bovine and the HbA model were 0.810 and 0.792 at site 1, and 0.928 and 0.924 at site 2. The inter-site inter-vendor correlation was 0.849 for ASE-OEF and 0.814 for TRUST-OEF based on the bovine model. ASE-OEF was significantly associated with TRUST-OEF (p<0.001).

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