Keywords: Data Processing, DSC & DCE Perfusion, Whole-brain bolus arrival timesDynamic susceptibility contrast imaging has used bolus arrival time (BAT) in tissue, relative to an arterial input function (AIF), as a nuisance variable when deriving perfusion metrics (e.g. blood flow). However, BAT reflects physiological changes in both fluid dynamics of feeding vasculature and capillary inflow. This work presents a reproducible approach for reliable and repeatable quantification of an AIF and whole brain BAT, which itself may be germane to chronic and acute cerebrovascular disease (CVD), such as white matter hyperintensities, age-associated CVD, and stroke.
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