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Abstract #3246

Reliable and repeatable fully automated bolus arrival times and arterial inputs using 2 Hz whole brain multiband DSC-MRI at 7T

Daniel L Schwartz1, Xin Li2, Fred Lesage3, Andreas Linninger4, Mohammad Jamshidi4, Becky Stone5, and William Rooney5
1Advanced Imaging Research Center/Neurology, OHSU, PORTLAND, OR, United States, 2Advanced Imaging Research Center, OHSU, PORTLAND, OR, United States, 3Electrical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 4Bioengineering, UIC, Chicago, IL, United States, 5Advanced Imaging Research Center, OHSU, Portland, OR, United States

Synopsis

Keywords: Data Processing, DSC & DCE Perfusion, Whole-brain bolus arrival timesDynamic susceptibility contrast imaging has used bolus arrival time (BAT) in tissue, relative to an arterial input function (AIF), as a nuisance variable when deriving perfusion metrics (e.g. blood flow). However, BAT reflects physiological changes in both fluid dynamics of feeding vasculature and capillary inflow. This work presents a reproducible approach for reliable and repeatable quantification of an AIF and whole brain BAT, which itself may be germane to chronic and acute cerebrovascular disease (CVD), such as white matter hyperintensities, age-associated CVD, and stroke.

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