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Abstract #3257

Quantitative assessment of HIF-1a expression in endometrial cancer by DCE-MRI combined ESWAN multiparameter imaging

Xie Zongyuan1, Tian Shifeng1, and Liu Ailian1
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China

Synopsis

Keywords: Uterus, CancerHypoxia -inducible factor (HIF-1α) is a major transcriptional factor regulating gene expression under hypoxic conditions. High expression of HIF-1α contributes to high aggressiveness or poor prognosis of cervical carcinoma. Multimodal MRI techniques DCE-MRI and ESWAN are new tools to determine the expression of HIF-1α.Its quantitative parameters Ktrans , Kep R2 * and T2* values were correlated with HIF-1a expression . Therefore,both DCE-MRI and ESWAN techniques can effectively evaluate HIF-1a expression in endometrial cance.

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