Abstract #3265

The value of amide proton transfer and glucose-chemical exchange saturation transfer in predicting tumor grading and staging in cervical cancer

Han Jiang¹, Nan Meng², Ziqiang Li¹, Bo Dai², Pengyang Feng³, Yu Luo², Zhiwei Shen⁴, and Meiyun Wang*²

¹Department of Medical Imaging, Xinxiang Medical University & Henan Provincial People's Hospital, Zhengzhou, China, ²Department of Medical Imaging, Zhengzhou University People's Hospital & Henan Province People's Hospital, Zhengzhou, China, ³Department of Medical Imaging, Henan University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, ⁴Philips healthcare, Beijing, China

Synopsis

Keywords: Pelvis, CEST & MT, cervical cancerWhat are the values of three-dimensional amide proton transfer (APT) imaging and glucose-chemical exchange saturation transfer (glucoCEST) in WHO grading and staging of cervical cancer? We performed 3D-APT, 3D-glucoCEST, and DWI scans in 19 cervical cancer cases. APT signal intensity（SI）, and GlucoCEST SI could distinguish high-grade from low-grade; GlucoCEST SI can differentiate early (<IIB) from advanced (≥IIB) cervical cancer. Both APT and glucoCEST can be used for the preliminary evaluation of cervical cancer, but glucose CEST has advantages in the evaluation of cervical cancer grading and staging.

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