Abstract #3266

Multi-exponential model of diffusion signal with fixed ADCs in healthy and cancerous cervix tissues

Ana E Rodríguez-Soto¹, Elin M Lundström^1,2,3, Alexandra Besser¹, Stephane Loubrie¹, Christopher C Conlin¹, Stephan Jordan¹, Summer Batasin¹, Sheida Ebrahimi¹, Alexandra Schlein¹, Michael Hahn¹, Tyler Seibert⁴, Anders M Dale^1,5, Marianne Tom-Hedla⁶, Cheryl Saenz⁶, Shira Varon⁶, Michael McHale⁶, and Rebecca Rakow-Penner¹

¹Radiology, University of California San Diego, La Jolla, CA, United States, ²Surgical Sciences, Uppsala University, Uppsala, Sweden, ³Radiology, Uppsala University, Uppsala, Sweden, ⁴Radiation Medicine, University of California San Diego, La Jolla, CA, United States, ⁵Neurosciences, University of California San Diego, La Jolla, CA, United States, ⁶Ob/Gyn & Reproductive Sciences, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Pelvis, CancerRestriction spectrum imaging (RSI) has shown potential to become a DWI-based, contrast-free diagnostic tool for cancer as it separates the different water pools in tissues. Here, we describe the diffusion signal of cancerous and healthy cervical tissues using RSI. Multi-exponential models with fixed ADCs were determined and the signal contribution of each component estimated. Initial results indicate that the slowest diffusion compartment of a tetra-exponential RSI model has the potential to isolate cervical cancer signal from that of surrounding tissues. This model may increase the sensitivity and specificity of DWI to evaluate response to treatment of cervical cancer patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.