Abstract #3272

Extending inhomogeneous MT to assess both neuromelanin and myelin in brainstem structures

Gopal Varma¹, Jane Fergusson², Asma Hassani², Aaron K Grant¹, Aron S Buchman³, David C Alsop¹, and Veronique VanderHorst²

¹Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ³Department of Neurological Sciences, Rush University Medical Center, Rush Alzheimer's Disease Center, Chicago, IL, United States

Synopsis

Keywords: Magnetization transfer, Neuro, BrainstemApplication of neuromelanin MRI (NM-MRI) in the brainstem has been utilized in studies of neurological disorders such as Parkinson's disease. Acquisition of two types of MT preparation for inhomogeneous MT, MT applied at a single offset and then dual off-resonance frequencies, presents an advancement to NM-MRI by providing an acquisition with a myelin sensitive signal for complementary information. We demonstrate this in ex-vivo brainstem samples at 9.4 T, which allows comparison with other MRI microstructural techniques, as well as in-vivo at 3 T, where MT images provide a contrast comparable to NM-MRI by fast-spin-echo.

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