Keywords: Relaxometry, White MatterQuantitative magnetization transfer (qMT) imaging can indirectly probe $$$R_2$$$ orientation dependence in WM for semisolid methylene protons from lipid bilayers. Prior experimental and simulation studies indicate that the long lipid chain not only rotates rapidly around itself, but it also wobbles in a cone. The existing modeling methods, however, did not take the latter motional mode into account, potentially leading to a biased measure of myelin-specific anisotropic $$$R_2$$$ relaxation. This work thus proposes a new model encompassing both motional modes for better characterizing an anisotropic $$$R_2$$$ profile of semisolid protons in WM.
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