Abstract #3275

Adiabatic Null Passage for on resonance magnetization transfer preparation

Shahrokh Abbasi-Rad^1,2,3,4 and David Norris^1,2

¹Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ²Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlsetown, MA, United States

Synopsis

Keywords: Magnetization transfer, RF Pulse Design & Fields, Adiabatic Null PassageOn-resonance bound pool saturation is the most efficient way of generating MTC. However, it suffers from excessive direct free water saturation due to RF pulse instabilities, and potential T2-weighting. We proposed a time-reversed adiabatic pulse (adiabatic null passage) for on-resonance MT preparation, by reversing the time-domain phase modulation function of a symmetric adiabatic pulse at its mid-point. We compared the MTC performance of ANP with binomial pulses using their MTR images. MTR values were reported through lines crossing CSF, showing high values at GM/WM and zero at CSF voxels. ANP improved the excessive saturation at regions with high B0 inhomogeneity.

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