Abstract #3283

The Influences on Amide Proton Transfer (APT) Signal Metrics at 3T: A Simulation and In-Vitro Study

Aisling Fothergill¹, David Higgins², Owen Thomas³, David Coope⁴, Ibrahim Djoukhadar³, and Laura Parkes¹

¹Geoffrey Jefferson Brain Research Centre, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, ²Philips, Farnborough, United Kingdom, ³Department of Radiology, Geoffrey Jefferson Brain Research Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Department of Academic Neurological Surgery, Geoffrey Jefferson Brain Research Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom

Synopsis

Keywords: CEST & MT, Quantitative Imaging, APT

Amide Proton Transfer MRI shows clinical benefit in glioma imaging. Clinically useful APTw metrics should be sensitive to changes in amide concentration, a potential marker of tumour proliferation, and insensitive to T₁ changes. To investigate sensitivity, simulations and in-vitro studies were performed over a range of amide concentrations and T₁ values. In-vitro data included two varied concentration series, with and without T₁-maintenance, and a constant concentration T₁-vaired series. In-vitro results showed APT* had poor sensitivity, MTR_rex was most sensitive to concentration and T₁, AREX may overcorrect for T₁, and MTR_asym appears least sensitive to T₁ while remaining sensitive to concentration.

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