Abstract #3285

Optimization and validation of Creatine- and Glutamate-CEST weighted imaging in the human brain at 7T

Bárbara Schmitz-Abecassis^1,2, Chloé Najac¹, Jaimy Plugge¹, Matthias J.P. van Osch^1,2, and Ece Ercan^1,3

¹Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Delta Cancer Diagnostics 3.0, South-Holland, Netherlands, ³Philips Healthcare, Best, Netherlands

Synopsis

Keywords: CEST & MT, High-Field MRIAmine chemical exchange saturation transfer (CEST) is highly sensitive for imaging metabolites in vivo. However, it lacks specificity. We aimed to develop and validate optimal CEST protocols to image creatine and glutamate in the human brain at 7T. Simulations were used to define optimal acquisition parameters, followed by in vitro validation. The optimal B₁rms and total saturation (t_sat) parameters were determined for creatine (B₁rms = 2.5μT & t_sat = 1500ms) and glutamate (B₁rms = 3.5μT & t_sat = 1000ms). These protocols were then used in healthy volunteers to investigate the correlation of glutamate- and creatine-weighted CEST with magnetic resonance spectroscopy results.

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