Abstract #3288

HyperCEST Potential of Members of the Cucurbit[n]uril Family: Revised Signal Assignment and Suitable Host Identification with Accelerated MRI

Leif Schröder¹, Hen Amit Morik¹, and Patrick Schuenke²

¹Translational Molecular Imaging, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany, ²Biomedical Magnetic Resonance, Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany

Synopsis

Keywords: Contrast Agent, CEST & MT

The full potential of the ultra-sensitive approach of HyperCEST MRI crucially depends on host structures with efficient release of hyperpolarized ¹²⁹Xe. Cucurbit[n]urils (CB6 and CB7) have been proposed as promising candidates but a quantitative analysis of CEST signatures yet remained an open question. Here, we use MRI-derived z-spectra of multiple samples which provide strong evidence that CB7 is unsuitable as CEST agent and that previously observed signals are solely assigned to CB6 which is also side product in CB7 synthesis. Image acquisition with >20-fold acceleration for the 4-dimensional datasets is possible without compromising a detailed quantitative analysis.

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