Abstract #3289

Maximization of cucurbit[6]uril hyperpolarized chemical exchange saturation transfer (HyperCEST) in bovine blood at 3.0 T

Vira Grynko^1,2, Viktoriia Batarchuk^2,3, Yurii Shepelytskyi^2,3, Hannah Aalto⁴, Joseph Deschamps⁴, Iulian Constantin Russet⁵, and Mitchell Albert^2,3,6

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁴Applied Life Science Program, Lakehead University, Thunder Bay, ON, Canada, ⁵Xemed LCC, Durham, NH, United States, ⁶Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Synopsis

Keywords: Hyperpolarized MR (Gas), Contrast Agent

Cucurbit[6]uril is a well-studied contrast agent for hyperpolarized ¹²⁹Xe (HP ¹²⁹Xe) MRI. Although the in vivobiodistribution of CB6 was measured with hyperpolarized chemical exchange saturation transfer (HyperCEST), there were no previous studies reported for maximization of the HyperCEST effect by optimization of depolarization pre-pulse trains. In the present work, we maximized the CB6 HyperCEST effect in bovine blood, and found for the first time, a HyperCEST depletion of the RBC resonance. In addition, the minimum detectable concentration was found to be four times lower than previously reported.

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