Abstract #3291

Feasibility of Mapping Intracellular NAD Content in Entire Human Brain at 7T

Xiao-Hong Zhu¹, Rong Guo^2,3, Hannes M Wiesner¹, Yudu Li^3,4, Yibo Zhao^3,5, Wen Jin^3,5, Zhi-Pei Liang^3,5, and Wei Chen¹

¹Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Siemens Medical Solutions USA, Inc., Urbana, IL, United States, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Quantitative Imaging, Metabolism, Human Brain NAD ImagingNicotinamide adenine dinucleotide (NAD) is an important molecule critical for cellular metabolism and signaling. The cerebral NAD concentration is only at submillimolar level, and thus, difficult to measure and imaging in vivo. In this study, we utilize 3D ³¹P MRSI-based NAD assay in combination with a SPICE-based signal processing method to evaluate the feasibility for non-invasively mapping the NAD contents in healthy human brains at 7T. The results suggest that by taking advantage of ultrahigh field scanner and advanced post-processing, it is possible to obtain whole-brain NAD maps with NAD measurements consistent with the literature reported values.

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