Abstract #3292

Spectrum of Brain Injury in COVID-19 Acute Respiratory Distress Syndrome: A Systematic Review of Neuroimaging Findings

Rachel Wagner^1,2, Michael T Jurkiewicz^2,3, Jennifer Chen^4,5, Angela Jerath^6,7, Marat Slessarev^2,5,8, and Udunna Anazodo^2,9

¹Neuroscience, Western University, London, ON, Canada, ²Lawson Health Research Institute, London, ON, Canada, ³Medical Imaging, London Health Sciences Centre, London, ON, Canada, ⁴Critical Care Medicine, Western University, London, ON, Canada, ⁵Western Institute for Neuroscience, Western University, London, ON, Canada, ⁶Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Evaluative Clinical Sciences, Schulich Heart Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁸Critical Care Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁹Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Infectious disease, COVID-19, NeuroscienceWhile most COVID-19 patients present with mild symptoms, many of those hospitalized with severe infection develop acute respiratory distress syndrome (ARDS)¹ and frequently report central nervous system dysfunction². While previous research has characterized clinical symptomatology, investigation regarding brain changes remains limited. To address this gap, this review summarized brain injuries from 372 COVID-19-ARDS and 370 ARDS patients and pooled findings. COVID-19-ARDS patients presented an unusual pattern of injury preferentially targeting white matter, suggesting impact to brain connectivity. The long-term consequences of white matter injury in COVID-19-ARDS should be taken into account in devising policies for managing patient health.

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