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Abstract #3296

Feasibility of whole-brain functional MRI with 1-mm isotropic resolution at 3T

Wei-Tang Chang1,2,3, Stephanie Langella4, Min Sung Seo5, Weili Lin2, and Kelly Giovanello5
1Biomedical Engineering, UNC at Chapel Hill, Chapel Hill, NC, United States, 2Biomedical Research Imaging Center, UNC at Chapel Hill, Chapel Hill, NC, United States, 3Radiology, UNC at Chapel Hill, Chapel Hill, NC, United States, 4Psychiatry, Harvard Medical School, Boston, MA, United States, 5Psychology & Neuroscience, UNC at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Data Acquisition, NeurofMRI with ultrahigh resolution has typically been acquired at 7T in order to overcome the inherently low SNR at 3T. However, 7T scanners are inaccessible to the majority of investigators. In this study, we developed new acquisition and reconstruction approaches and employed the denoising method NORDIC to improve the resolution of 3T fMRI to 1 mm isotropic with whole-brain coverage and volumetric scan time of 2 seconds. Our results showed improved tSNR and low spatial blurring. The detection capability of resting-state networks was comparable to that of 7T. BOLD activations in cortical and subcortical regions were observed in task-based fMRI.

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Keywords