Abstract #3296

Feasibility of whole-brain functional MRI with 1-mm isotropic resolution at 3T

Wei-Tang Chang^1,2,3, Stephanie Langella⁴, Min Sung Seo⁵, Weili Lin², and Kelly Giovanello⁵

¹Biomedical Engineering, UNC at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, UNC at Chapel Hill, Chapel Hill, NC, United States, ³Radiology, UNC at Chapel Hill, Chapel Hill, NC, United States, ⁴Psychiatry, Harvard Medical School, Boston, MA, United States, ⁵Psychology & Neuroscience, UNC at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Data Acquisition, NeurofMRI with ultrahigh resolution has typically been acquired at 7T in order to overcome the inherently low SNR at 3T. However, 7T scanners are inaccessible to the majority of investigators. In this study, we developed new acquisition and reconstruction approaches and employed the denoising method NORDIC to improve the resolution of 3T fMRI to 1 mm isotropic with whole-brain coverage and volumetric scan time of 2 seconds. Our results showed improved tSNR and low spatial blurring. The detection capability of resting-state networks was comparable to that of 7T. BOLD activations in cortical and subcortical regions were observed in task-based fMRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.