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Abstract #3299

Optimization of T1-Weighted DANTE-SPACE for Intracranial Vessel Wall Imaging at 7T

Xiangchuang Kong1, Jun Ma2, Erin Westerhold1, Eric H. Middlebrooks1, Shengzhen Tao1, Chen Lin1, and Xiangzhi Zhou1
1Department of Radiology, Mayo Clinic, Jacksonville, FL, United States, 2Siemens Medical Solutions USA, Inc., Jacksonville, FL, United States

Synopsis

Keywords: Blood vessels, High-Field MRI, DANTE, SPACE, 7TMR vessel-wall-imaging (VWI) is used clinically for noninvasive characterization of vessel wall pathology. The DANTE preparation module has been combined with conventional 3D-T1W-SPACE to achieve better slow-flow-suppression. 7T could further improve VWI by its increased SNR and spatial-resolution. Here we sought to optimize DANTE preparation module for T1W-SPACE at 7T. Simulations were done to determine the optimal parameters for the DANTE module. Human scans showed that the optimized T1W- DANTE-SPACE at 7T efficiently suppressed slow-blood-flow in both intracranial arteries and veins, and in turn improved wall contrast compared with conventional T1W-SPACE.

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Keywords