Abstract #3306

Mapping sodium relaxation parameters in brain using magnetic resonance fingerprinting at 7T

Lauren F O'Donnell¹, Gonzalo Rodriguez¹, Gregory Lemberskiy¹, Zidan Yu^1,2,3, Olga Dergachyova¹, Martijn A Cloos^4,5, and Guillaume Madelin¹

¹Department of Radiology, Center for Biomedical Imaging, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States, ³Vilcek Institute for Graduate Biomedical Sciences, NYU Langone Health, New York, NY, United States, ⁴Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia, ⁵ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, QLD, Australia

Synopsis

Keywords: MR Fingerprinting/Synthetic MR, Brain, Sodium, x - nuclei, relaxometry, 7 Tesla

We present a new MRF technique for simultaneous mapping of sodium T₁, biexponential T₂*, ion density, B⁺₁ shift and B₀ in the brain at 7T. This is accomplished using a 23 pulse MRF train combined with a UTE FLORET trajectory readout. Our technique is demonstrated in a 3 compartment phantom and in vivo across four healthy volunteers. Matching to a dictionary with over 800,000 signals produced parameter maps with good agreement to literature values. Flow and partial volume effects may interfere with matching T*_2,shortin CSF.

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