Abstract #3307

High-Resolution Myelin Water Imaging Using MPnRAGE

Jayse Merle Weaver^1,2, Steven Kecskemeti², Jose M Guerrero-Gonzalez^1,2, Andrew L Alexander^1,2,3, and Douglas C Dean III^1,2,4

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, ³Psychiatry, University of Wisconsin-Madison, Madison, WI, United States, ⁴Pediatrics, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Quantitative Imaging, Brain, MyelinA T1-only method to extract a quantitative myelin water fraction, utilizing a 3D radial k-space MPnRAGE sequence that reconstructs hundreds of different inversion time (TI) images in the same scan used for high-resolution T1-weighted morphometry was developed. To address high sensitivities to additive image noise of this complex model, a multi-pass fitting algorithm was prototyped that provides educated initial guesses and constraints on the underlying parameters.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.