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Abstract #3307

High-Resolution Myelin Water Imaging Using MPnRAGE

Jayse Merle Weaver1,2, Steven Kecskemeti2, Jose M Guerrero-Gonzalez1,2, Andrew L Alexander1,2,3, and Douglas C Dean III1,2,4
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 3Psychiatry, University of Wisconsin-Madison, Madison, WI, United States, 4Pediatrics, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Quantitative Imaging, Brain, MyelinA T1-only method to extract a quantitative myelin water fraction, utilizing a 3D radial k-space MPnRAGE sequence that reconstructs hundreds of different inversion time (TI) images in the same scan used for high-resolution T1-weighted morphometry was developed. To address high sensitivities to additive image noise of this complex model, a multi-pass fitting algorithm was prototyped that provides educated initial guesses and constraints on the underlying parameters.

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Keywords