Keywords: Alzheimer's Disease, Alzheimer's DiseaseThis work explores the link between the topological properties of brain structural networks and APOE-epsilon4 in young asymptomatic adults. We investigated the sensorimotor, visual and default-mode networks. We found evidence that there are differences in the mean clustering coefficient of the sensorimotor network of carriers versus non-carriers, with the left caudal middle frontal, left precentral, right postcentral and right precentral gyri driving the differences. Interestingly, the mean clustering coefficient was higher in carriers compared to non-carriers. In contrast, no differences were found for the visual or the default-mode networks.
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