Abstract #3318

Hyperactive BOLD response in presymptomatic AD mice model as potential biomarker of early AD

Taeyi You^1,2, Taekwan Lee³, Geun Ho Im¹, Seong-gi Kim¹, Sungkwon Chung⁴, and Jung Hee Lee⁵

¹Center for Neuroscience Imaging Research, Institute of Basic Science, Suwon, Korea, Republic of, ²Biomedical Engineering, Sungkyungkwan University, Suwon, Korea, Republic of, ³Korea Brain Research Institute, Daegu, Korea, Republic of, ⁴Physiology, Sungkyunkwan University, Suwon, Korea, Republic of, ⁵Radiology, Samsung Medical Center, Seoul, Korea, Republic of

Synopsis

Keywords: Alzheimer's Disease, fMRI (task based)Alzheimer Disease is a neurodegenerative disease that exhibits memory and cognitive deficits. Majority of research has targeted these late-stage biomarkers as treatment targets, yet all have failed in the clinical settings. Detection of early biomarkers is becoming imperative that can be easily and effectively used. fMRI is a quick and non-invasive procedure that can map whole brain activity. Here we use sensory evoked fMRI in a AD mouse model to show longitudinal changes in brain response that can be potential biomarkers for early AD.

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