Abstract #3319

MRI phenotypes of the brain are related to long-term dementia outcome in community-dwelling older adults

Jasmin A. Keller¹, Sigurdur Sigurdsson ², Bárbara Schmitz Abecassis ¹, Ilse M.J. Kant ^3,4, Mark A. van Buchem¹, Lenore J. Launer⁵, Matthias J.P. van Osch¹, Vilmundur Gudnason^2,6, and Jeroen H.J.M. de Bresser¹

¹Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Icelandic Heart Association, Kopavogur, Iceland, ³Clinical Artificial Intelligence Implementation and Research Lab (CAIRELab) and Department of Information Technology & Digital Innovation, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Digital Health, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, United States, ⁶Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Synopsis

Keywords: Dementia, Aging, Cerebral small vessel diseaseIndividual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals at increased risk for dementia. We implemented a combined hierarchical clustering analysis based on neurodegenerative and neurovascular brain MRI markers and identified 14 distinct subgroups of individuals with different brain MRI phenotypes. These subgroups had a different long-term risk for dementia; especially the multi-burden brain MRI phenotype showed an increased risk (HR: 13.8 (95%-CI:4.28-44.37)). These findings may in the future be useful to determine patient prognosis and may aid in patient selection for future treatment studies.

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