Abstract #3321

Associations between CSF Biomarkers of Alzheimer's Disease and Subcortical Volume in Healthy Aging

Qixiang Lin¹, Shuai Huang², Aditya Bisht¹, Allan Levey^1,3, James Lah^1,3, and Deqiang Qiu^2,3,4

¹Department of Neurology, Emory University, Atlanta, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ³Goizueta Alzheimer’s Disease Research Center, Emory University, Atlanta, GA, United States, ⁴Joint Department of BioMedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States

Synopsis

Keywords: Alzheimer's Disease, Aging, CSF biomarker; Aβ; Tau; Subcortical; VolumeThis study aims to evaluate the association between subcortical volumes and cerebrospinal fluid (CSF) biomarkers of Alzheimer’s Disease (AD) in a large group of healthy aging from a single center. CSF samples were obtained and quantitative levels of amyloid-β and Tau were measured. Subcortical tissue segmentations were performed on T1-weighted MPRAGE scans and the volume of each subcortical structure were calculated. Significant correlations were found between CSF biomarkers of AD and volume of the right and the left caudate. This may indicate that the volume of caudate are associated with CSF AD biomarker in healthy aging participants.

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