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Abstract #3327

Accelerating 3T MRI standardized protocol for detection of Amyloid Related Imaging Abnormality (ARIA) using Philips SmartSpeed

Sandeep Ganji1,2, Brian Johnson3,4, Spencer Waddle1, Johannes Peeters5, Laszlo Mechtler6, and Nandor Pinter6,7
1Philips, Rochester, MN, United States, 2Mayo Clinic, Rochester, MN, United States, 3Philips, Gainesville, FL 32608, FL, United States, 4University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Philips, Eindhoven, Netherlands, 6Dent Neurologic Institute, Buffalo, NY, United States, 7Department of Neurosurgery, University at Buffalo, Buffalo, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's DiseaseAmyloid Related Imaging Abnormality (ARIA) was reported in 40% of patients treated with anti-amyloid beta drugs in phase 3 trials. It is expected to be a significant factor in the clinical application of new Alzheimer’s Disease (AD) modifying therapies and requires standardized and practical imaging. By employing Compressed-SENSE (CS-SENSE) and newer deep learning based SmartSpeed to accelerate acquisition we created a robust MRI protocol that can be completed in under ten minutes without loss of any image quality. This accelerated protocol can provide a clinically feasible strategy for scanning large populations.

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