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Abstract #3330

­Neuropathology and neurometabolites in mild cognitive impairment investigated with 11C-PiB amyloid PET and 7T MRS

Christopher William Davies-Jenkins1,2, Kathleen E Hupfeld1,2, Helge J Zöllner1,2, Gwenn S Smith3,4, and Georg Oeltzschner1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD, United States, 4Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, MRS, PET, Amyloid, 7T, MCIMild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is increasingly studied by multi-modal beta-amyloid (Aβ) PET and MRS. Most studies have targeted the PCC and a limited number of metabolites. In this study, we analyzed Aβ PET and 7T 1H-MRS data from the ACC and PCC of MCI patients and healthy controls, using a voxel-specific Aβ metric. Metabolite-amyloid correlations were investigated using multiple regression analysis. We report a novel finding of a differential GABA-amyloid relationship for MCI patients compared with controls in the ACC and support previous reports of amyloid relationships with NAA and myo-inositol.

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