Abstract #3331

Altered brain function and structure in a transgenic mouse which overexpress MTH1 hydrolase following an oxidative stimulus by rs-fMRI and DTI

Taljinder Singh^1,2, Francesco de Pasquale³, Gabriele De Luca⁴, Paola Fortini⁵, Valeria Simonelli⁵, and Rossella Canese¹

¹MRI Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy, ²Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy, ³University of Teramo, Teramo, Italy, ⁴Oncology and Molecular Medicine Dept., Istituto Superiore di Sanità, Rome, Italy, ⁵Environmental and Health Dept., Istituto Superiore di Sanità, Rome, Italy

Synopsis

Keywords: Brain Connectivity, Animals, DTI, oxidant agent

Oxidative stress is involved in the pathogenesis of cancer, neurodegeneration and aging. hMTH1 is a hydrolase able to protect cells by oxidative damage. Overexpression of hMTH1 in transgenic mice confers significant protection against oxidative damage. Our study showed alterations in the brain networks of hMTH1-Tg mice with respect to their controls. The chronical exposure to an oxidant agent (Paraquat, most widely used herbicide) causes differences in the brain function (measured by rs-fMRI) and structure (measured by DTI) of transgenic mice.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.