Abstract #3333

Altered Resting-State Network Connectivity in Essential Tremor

Sheng-Min Huang¹, Yu-Chin Huang², Nan-Hao Chen³, Chun-Ying Shen⁴, Ting-Kai Leung^4,5, and Li-Wei Kuo^1,6

¹Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ²Department of Neurology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, ³Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ⁴Department of Radiology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, ⁵Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ⁶Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

Synopsis

Keywords: Brain Connectivity, fMRI (resting state), essential tremorWe aim to characterize the functional connectivity in essential tremor to portray the resting-state network organization and its correlation to tremor features. Reduced functional connectivity between default mode network and ventral attention network was found in essential tremor subjects. The inter-network connectivity and intra-network connectivity were also shown to be associated with tremor features. Our result suggest that analysis of resting-state network is a potential approach in detecting the cerebral alterations in ET.

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