Abstract #3334

Functional Connectivity between Right Rolandic Operculum and Default Mode Network Is Associated with Chronic Low Back Pain-Related Disability

Chang-Min Chen¹, Shwu-Fen Wang², Dar-Ming Lai³, and Wen-Chau Wu¹

¹Institute of Medical Device and Imaging, National Taiwan University, Taipei, Taiwan, ²Department of Physical Therapy, National Taiwan University, Taipei, Taiwan, ³Department of Surgery, National Taiwan University, Taipei, Taiwan

Synopsis

Keywords: Brain Connectivity, fMRI (resting state)This study aimed to explore the relationship between emotion and pain-related disability in patients with chronic low back pain (CLBP) by using resting-state functional connectivity (FC). Our results showed that as compared with the control group (n = 26), the patient group (n = 26) had decreased FC with the default mode network in multiple brain regions. Specifically, the right Rolandic operculum was identified, where FC was inversely correlated with the Oswestry disability index (r = -0.616, p < 0.001), suggesting the interplay between emotion processing and pain perception.

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